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Fitbit’s market share is nearly 85%. which means having up to 1 drink per day for women and up to 2 drinks per day for men. missed the concert), Police say that team had been dispatched to another incident. a national advocacy group, Since the 14-year-old had returned to Wisconsin from a family trip to Puerto Rico, The Center for Rural Affairs in Lyons Neb: " target="_blank">wwwcfraorg/resources/beginning_farmer Jacobson saidm Farmers’ agitation turns violent as they torch trucks at Mhow-Neemuch Highway in Mandsaur district of Madhya Pradesh on 7 June In factTreating Alzheimers likely wont ever be an easy or simple thing Researchers think that managing the disease will require a combination of treatments possibly tailored to each person But in a paper published Wednesday in the journal Nature scientists from a biotech company report the most encouraging results so far for one drug that could play a key role Researchers at Biogen say that the antibody they have been testing can bind to and break down the amyloid protein that builds up in abnormal amounts in the brains of Alzheimers patients Even more encouraging they report that for a small number of people in the study that reduction in amyloid plaques was linked to a slowing in the cognitive decline associated with Alzheimers "We are pretty certain of the fact that the antibody reduces the amyloid plaques and in some ways gets rid of the majority of it" says Alfred Sandrock senior author of the paper from Massachusetts-based Biogen "Thats important because if we really want to treat Alzheimers at even the very earliest stages then we felt it was important for our antibody to remove the plaque thats already there" The results of the trial which Biogen has revealed in pieces at previous scientific conferences shows that the higher the dose of the antibody called aducanumab the more amyloid is removed In the trial of 165 people with mild to moderate Alzheimer’s participants were randomly assigned to receive either placebo or one of three different doses of the drug After a year of monthly infusions those receiving the highest doses showed the most reduction in amyloid compared to the start of the study The small number of people who were tested on cognitive function showed promising signs that reducing the amount of amyloid in the brain might translate into improved function but thats just an early hint The company is recruiting people for two other ongoing trials that aim to answer that question So far though the drug seems to slow the cognitive decline; whether this decline can return brains to their pre-amyloid pre-Alzheimers function wont be known until the additional studies are completed What happens when amyloid builds up in the brain is a complex process that involves damage some of it permanent to nerves and neural networks But animal work showed that some nerves surrounding amyloid plaques were restored to close to their original function providing hope that it might be possible to recover at least some cognitive function if amyloid plaques are removed Its not clear yet exactly how the antibody is melting away the plaque but studies in animals may provide a clue In earlier trials researchers think the aducanumab is breaking down the amyloid and attracting the bodys immune system to dispatch the remnants specifically a class of cells known as microglia which can digest biological residue Aducanumab is one of several anti-amyloid strategies that companies are pursuing to treat Alzheimers Biogen believes its compound has an advantage in that it doesnt bind to amyloid that most people have circulating in the blood; instead it preferentially targets the amyloid that is aggregated in plaques in the brain which Alzheimers experts believe is the most toxic form of the protein and responsible for the diseases symptoms of memory problems and cognitive decline The drug is not without side effects The people getting the highest dose showed higher rates of a brain swelling thats been linked with aducanumab and other drugs in earlier trials About 41% of those receiving the drug at any dose showed this side effect Stephen Salloway professor of neurology and psychiatry at Brown University and one of the co-authors of the paper says that swelling could be monitored with more frequent brain scans The researches also learned that people with a genetic predisposition to developing Alzheimers are also at higher risk of developing the side effect Salloway says that more studies will be needed to understand what is causing the swelling but its possible that the dramatic change in amyloid could be the major factor Most of the swelling occurs soon after people start taking the drug and it subsides if they stop the treatment "At this point I would not be so concerned that I would advise people not to participate in the trials of the drug" says James Hendrix director of global science initiatives at the Alzheimers Association "Its something the company is keenly aware of that the Food and Drug Administration is keenly aware of and the we just need to see if we can manage the risk Im very excited by these results" If the additional studies confirm these early results its possible that aducanumab could be used as a preventive therapy doctors prescribe to people who might be at higher risk of developing Alzheimers Routine screening for amyloid could also become more common if treatments like these become available so that doctors can find those who might benefit most from these medications and stop the disease before it really takes hold Contact us at editors@timecomOver the last three months Apple grew its revenues by 33% saw its profits increase by 38% to $107 billion put away more than $202 billion in cash for a rainy day and yet lost more than $60 billion in market value in just three minutes on Tuesday Casual observers might be scratching their heads at news that at first glance would suggest the world’s biggest tech company had a bad day despite releasing earnings many companies would be proud to call their own “Apple iPhone Sales Up 35% Disappoint Investors" was the Wall Street Journal‘s initial headline “Apple Profit Up 38% but iPhone Sales Disappoint Wall Street” blared The New York Times The reason for this initially mind-boggling disparity Expectations Before companies like Apple release their latest earnings reports analysts try to guess what those numbers might reveal These analysts typically employed by brokerage firms are tasked with providing accurate assessments for investors who want to know if they should buy more stock hold their current position or sell their shares Analysts’ forecasts are then culled together to produce a consensus earnings estimate for a company If a company beats these estimates it usually portends good fortune for their market value as investors flock to buy up stock of the company If the company fails to meet expectations however market sentiment shifts against them sometimes resulting in a selloff like the one we saw in after-hours Apple trading Tuesday evening The Brief Newsletter Sign up to receive the top stories you need to know right now View Sample Sign Up Now Apple is perhaps a victim of its own success It routinely beat earnings estimates over the last four quarters setting high expectations this time for another rout In its previous earnings report Apple recorded its most profitable second quarter ever with revenues of $58 billion handily beating a consensus estimate of around $56 billion The fact that Apple sold almost 612 million iPhones in that quarter a number that also beat predictions of 568 million also delighted investors as the iPhone is an increasingly important part of Apple’s bottom line Immediately Apple’s share price was up 125% reaching an all-time high of $134 But this time around Apple missed the mark on its closely-watched iPhone sales The 475 million units it sold while still a third quarter record was below the estimate of around 50 million units And while iPhone sales grew by 35% that figure was down from the 40% growth in the previous quarter and the 46% growth two quarters earlier Apple’s own forward-looking revenue projections too came in below Wall Street expectations hence the bad vibes after Tuesday’s earnings report "While total company and iPhone revenue growth accelerated in the June quarter iPhone units missed expectations” said Morgan Stanley Analyst Katy Huberty Read next: What Apples Bizarre Stock Tumble Really Means Download TIMEs mobile app for iOS to have your world explained wherever you go This story originally appeared on Fortunecom Contact us at editors@timecom making the technology,S.

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